ENERGY-DEPENDENT PROTEIN FOLDING: MODELING HOW A PROTEIN FOLDING MACHINE MAY WORK [VERSION 1; PEER REVIEW: 1 APPROVED, 2 APPROVED WITH RESERVATIONS]

Energy-dependent protein folding: modeling how a protein folding machine may work [version 1; peer review: 1 approved, 2 approved with reservations]

Background: Proteins fold robustly and reproducibly in vivo, but many cannot fold in vitro in isolation from cellular components.Despite the remarkable progress that has been achieved by the artificial intelligence approaches in predicting the protein native conformations, the pathways that lead to such conformations, either in vitro or in vivo, re

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Constraints on scalar leptoquarks from lepton and kaon physics

Abstract We present a comprehensive analysis of low-energy signals of hypothetical scalar leptoquark interactions in lepton and kaon transitions.We derive the most general effective four-fermion Lagrangian induced by tree-level scalar leptoquark exchange and identify the Wilson coefficients predicted by the five possible types of scalar leptoquarks

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Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.

We analyzed the effects of dopamine signaling on the temporal organization of rest and activity in Drosophila melanogaster.Locomotor behaviors were recorded using a video-monitoring system, and the amounts of movements were quantified by using an image processing program.We, first, confirmed that rest bout durations followed long-tailed (i.e., powe

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Utilizing metagenomic next-generation sequencing and phylogenetic analysis to identify a rare pediatric case of Naegleria fowleri infection presenting with fulminant myocarditis

BackgroundNaegleria fowleri (N.fowleri), a rare and wx gloves typically lethal amoeba, most commonly causes primary amoebic meningoencephalitis (PAM).This case report describes an exceptionally rare presentation of fulminant myocarditis as the primary manifestation in a 6-year-old child, diverging from the typical neurological pathogenesis associat

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An Investigation to Reduce the Effect of Moisture on Injection-Molded Parts through Optimization of Plasticization Parameters

Plastic materials can absorb moisture from the atmosphere even after drying.This absorbed moisture can cause many defects in the molding process.Conventionally, a dryer is used to reduce the moisture content.However, the use of a drying unit involves huge daily power consumption and is also time-consuming.Therefore, this study proposed a new method

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